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[原发性甲状旁腺腺瘤溶酶体中铝浓度异常]

[Abnormal concentration of aluminium in the lysosomes of a primary parathyroid adenoma].

作者信息

Galle P, Campos H, Chadenas D

出版信息

Ann Pathol. 1987;7(1):65-8.

PMID:3620022
Abstract

A primitive parathyroid adenoma has been studied by electron microscopy, analytical ion microscopy and electron probe X ray analysis. A number of lysosomal structures has been observed in the cells. Observation of unstained ultrathin sections shows that these lysosomes contain two varieties of structures: dense homogeneous droplets and very dense and small granulations. Aluminium associated with phosphorus has been detected in high concentration in the small granulations. The relations between aluminium and parathyroid function and the possible role of aluminium in the pathology of the parathyroid gland remain to be clarified.

摘要

通过电子显微镜、分析离子显微镜和电子探针X射线分析对一个原发性甲状旁腺腺瘤进行了研究。在细胞中观察到了许多溶酶体结构。对未染色超薄切片的观察表明,这些溶酶体包含两种结构:致密均匀的液滴和非常致密的小颗粒。在小颗粒中检测到高浓度的与磷相关的铝。铝与甲状旁腺功能之间的关系以及铝在甲状旁腺病理学中的可能作用仍有待阐明。

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