Roine R P, Ylikahri R, Koskinen P, Suokas A, Hämäläinen J, Salaspuro M
Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Finland.
Alcohol. 1987 Nov-Dec;4(6):509-11. doi: 10.1016/0741-8329(87)90094-2.
The effect of acute heavy alcohol consumption on urinary dolichol levels was studied in 10 healthy volunteers during 2 separate weekends (48 hr). During one of the weekends the subjects received alcohol 5.5 g of per kg body weight in 4 different sessions. The other weekend was otherwise identical, but no alcohol was served. During the weekend when the subjects consumed alcohol, urinary dolichol levels began to rise significantly on the second day of the experiment reaching more than double of the baseline values 42 hours after the beginning of the experiment. During the control weekend, no such increase in urinary dolichol levels was observed. Thus, heavy drinking lasting more than one day is capable of increasing urinary dolichol levels.
在两个不同的周末（48小时）对10名健康志愿者进行了急性大量饮酒对尿中多萜醇水平影响的研究。在其中一个周末，受试者在4个不同时段摄入每公斤体重5.5克酒精。另一个周末情况相同，但未提供酒精。在受试者饮酒的那个周末，实验第二天尿中多萜醇水平开始显著升高，在实验开始42小时后达到基线值的两倍多。在对照周末，未观察到尿中多萜醇水平有此类升高。因此，持续一天以上的大量饮酒能够升高尿中多萜醇水平。
