Roine R P
Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Finland.
Alcohol. 1988 May-Jun;5(3):229-31. doi: 10.1016/0741-8329(88)90057-2.
Urinary dolichols were studied during a period of 10 days of moderate drinking (60 g of alcohol daily), preceded and followed by a period of abstinence, in 10 healthy volunteers. No significant changes were observed in dolichol levels during this time. Thus, moderate alcohol consumption does not affect urinary dolichols. Furthermore, to establish the time of abstinence needed for elevated urinary dolichol levels to return to normal, 17 alcoholic patients entering a detoxification unit and with initially increased urinary dolichols, were followed for seven days. Mean urinary dolichol level, which was clearly elevated in the beginning of detoxification, returned to normal by the 5th day of the treatment. Half-life decay for increased urinary dolichols was found to be about 3 days.
在10名健康志愿者中，研究了他们在适度饮酒（每天60克酒精）10天期间以及戒酒前后的尿多萜醇情况。在此期间，未观察到多萜醇水平有显著变化。因此，适度饮酒不影响尿多萜醇。此外，为确定尿多萜醇水平升高恢复正常所需的戒酒时间，对17名进入戒毒所且最初尿多萜醇升高的酒精成瘾患者进行了为期7天的跟踪。解毒开始时明显升高的尿多萜醇平均水平在治疗第5天时恢复正常。发现尿多萜醇升高的半衰期约为3天。
