哌甲酯治疗改善注意缺陷多动障碍青少年的情感共情而非认知共情。
Treatment with Methylphenidate Improves Affective but Not Cognitive Empathy in Youths with Attention-Deficit/Hyperactivity Disorder.
作者信息
Fantozzi Pamela, Muratori Pietro, Caponi Maria Celeste, Levantini Valentina, Nardoni Cristina, Pfanner Chiara, Ricci Federica, Sesso Gianluca, Tacchi Annalisa, Milone Annarita, Masi Gabriele
机构信息
IRCCS Stella Maris Foundation, Scientific Institute of Child Neurology and Psychiatry, Calambrone, 56128 Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
出版信息
Children (Basel). 2021 Jul 14;8(7):596. doi: 10.3390/children8070596.
BACKGROUND
Beside the core symptoms, patients with attention-deficit/hyperactivity disorder (ADHD) frequently show relevant difficulty in developing relationships with peers. Although ADHD symptoms may account for social impairment, deficits in cognitive and/or affective empathy have also been involved. Our aim was to investigate the effect of methylphenidate (MPH) treatment on affective and cognitive empathy.
METHODS
Sixty-one drug-naïve youths with ADHD (age range 6 to 17 years, mean 10.3 ± 2.8 years, 51 males) naturalistically treated with MPH monotherapy were followed up for 6 months for ADHD symptoms and empathy, measured with the Basic Empathy Scale.
RESULTS
After being treated with MPH, the patients showed a significant improvement in affective and cognitive empathy scores. Linear regression models showed that changes in inattention symptoms predicted changes in affective but not in cognitive empathy, while changes in the hyperactivity/impulsivity symptoms did not predict changes in affective or cognitive empathy.
CONCLUSIONS
Our study provides a further contribution for a better understanding of the possible effects of the MPH on youth's characteristics.
背景
除核心症状外，注意缺陷多动障碍（ADHD）患者在与同伴建立关系方面常常存在显著困难。尽管ADHD症状可能导致社交障碍，但认知和/或情感共情缺陷也与之相关。我们的目的是研究哌甲酯（MPH）治疗对情感和认知共情的影响。
方法
对61名未服用过药物、接受MPH单一疗法自然治疗的ADHD青少年（年龄范围6至17岁，平均10.3±2.8岁，51名男性）进行为期6个月的随访，观察ADHD症状及共情情况，采用基本共情量表进行测量。
结果
接受MPH治疗后，患者的情感和认知共情得分有显著改善。线性回归模型显示，注意力不集中症状的变化可预测情感共情的变化，但不能预测认知共情的变化，而多动/冲动症状的变化既不能预测情感共情的变化，也不能预测认知共情的变化。
结论
我们的研究为更好地理解MPH对青少年特质的可能影响提供了进一步的贡献。
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