Das Bibhuti B, Moskowitz William B, Taylor Mary B, Palmer April
Department of Pediatrics, Children's of Mississippi Heart Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Department of Pediatrics, Division of Critical Care, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Children (Basel). 2021 Jul 18;8(7):607. doi: 10.3390/children8070607.
This is a cross-sectional study of 29 published cases of acute myopericarditis following COVID-19 mRNA vaccination. The most common presentation was chest pain within 1-5 days after the second dose of mRNA COVID-19 vaccination. All patients had an elevated troponin. Cardiac magnetic resonance imaging revealed late gadolinium enhancement consistent with myocarditis in 69% of cases. All patients recovered clinically rapidly within 1-3 weeks. Most patients were treated with non-steroidal anti-inflammatory drugs for symptomatic relief, and 4 received intravenous immune globulin and corticosteroids. We speculate a possible causal relationship between vaccine administration and myocarditis. The data from our analysis confirms that all myocarditis and pericarditis cases are mild and resolve within a few days to few weeks. The bottom line is that the risk of cardiac complications among children and adults due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection far exceeds the minimal and rare risks of vaccination-related transient myocardial or pericardial inflammation.
这是一项对29例已发表的新冠病毒mRNA疫苗接种后急性心肌心包炎病例的横断面研究。最常见的表现是在第二剂新冠病毒mRNA疫苗接种后1至5天内出现胸痛。所有患者肌钙蛋白均升高。心脏磁共振成像显示，69%的病例有与心肌炎相符的晚期钆增强。所有患者在1至3周内临床迅速康复。大多数患者接受了非甾体抗炎药治疗以缓解症状，4例接受了静脉注射免疫球蛋白和皮质类固醇治疗。我们推测疫苗接种与心肌炎之间可能存在因果关系。我们分析的数据证实，所有心肌炎和心包炎病例均为轻度，在几天至几周内即可痊愈。关键在于，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染在儿童和成人中引发心脏并发症的风险远远超过疫苗接种相关短暂性心肌或心包炎症的极小且罕见风险。
