不同抗凝水平下各维生素K依赖性凝血因子之间的相互关系。
Inter-relationship among individual vitamin K-dependent clotting factors at different levels of anticoagulation.
作者信息
Chan E, Aarons L, Serlin M, Breckenridge A, Rowland M
机构信息
Pharmacokinetics Department, University of Manchester.
出版信息
Br J Clin Pharmacol. 1987 Nov;24(5):621-5. doi: 10.1111/j.1365-2125.1987.tb03221.x.
Abstract
- The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.
摘要
- 在五名完成抗凝治疗疗程的患者中，研究了亚治疗剂量华法林对四种维生素K依赖性凝血因子活性在稳态时的影响。2. 对于给定剂量的华法林，四种凝血因子活性显示出类似程度的降低。3. 凝血酶原复合物活性显著低于任何一种凝血因子的活性。
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