胺碘酮对华法林抗凝作用的增强作用。
The potentiation of warfarin anticoagulation by amiodarone.
作者信息
Hamer A, Peter T, Mandel W J, Scheinman M M, Weiss D
出版信息
Circulation. 1982 May;65(5):1025-9. doi: 10.1161/01.cir.65.5.1025.
PMID:7074739
Abstract
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
摘要
据报道，10例患者使用胺碘酮后华法林钠的抗凝作用增强。胺碘酮似乎通过一种不确定的机制增强了华法林引起的维生素K依赖凝血因子的降低，并且可能导致严重出血。当胺碘酮与华法林联合使用时，华法林的维持剂量应减半。
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