Department of General Surgery, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, Turkey.
Department of Biochemistry, Medicine of Faculty, Haliç University, Istanbul 34445, Turkey.
Medicina (Kaunas). 2021 Jul 8;57(7):698. doi: 10.3390/medicina57070698.
: Studies on hematological parameters in the differential diagnosis of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) are limited. This study investigated whether preoperative fibrinogen and hematological indexes can be used in the differential diagnosis of patients with IGM and early-onset BC. : Fifty patients with BC, 55 patients with IGM, and 50 healthy volunteer women were included in the study. : There was a statistically significant difference between the IGM and the BC with respect to fibrinogen, fibrinogen/albumin (Fib/Alb) ratio, C-reactive protein (CRP), white blood cells (WBC), neutrophils, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte values. When fibrinogen ( < 0.001), the Fib/Alb ratio ( < 0.001), CRP ( < 0.001), WBC ( < 0.001), neutrophil ( < 0.001), NLR ( < 0.001), monocyte ( = 0.008), and 2-hour sedimentation rate ( < 0.001) were compared between the groups, the highest levels were found in the IGM group. There was a negative relationship between CRP and albumin, and a positive relationship was observed between CRP and WBC, NLR, PLR, and 2-h sedimentation rate. CRP had the highest sensitivity (95%), whereas the Fib/Alb ratio (86%) had the highest specificity. Patients with recurrent IGM had increased fibrinogen, Fib/Alb, CRP, neutrophils, NLR, and 2-h erythrocyte sedimentation rate (ESR) and decreased lymphocyte levels compared to non-recurrent patients. : Preoperative CRP, albumin, fibrinogen, Fib/Alb, WBC, neutrophil, NLR, monocyte, and 2-h ESR have considerable potential to be early and sensitive biomarkers of IGM caused by inflammation compared to BC. These parameters also have a significant effect on the recurrence of the disease, suggesting their potential as a practical guide for the differential diagnosis of BC from IGM.
: 关于特发性肉芽肿性乳腺炎（IGM）和乳腺癌（BC）鉴别诊断的血液学参数研究有限。本研究旨在探讨术前纤维蛋白原和血液学指标是否可用于鉴别诊断 IGM 和早发性 BC 患者。 : 本研究纳入了 50 例 BC 患者、55 例 IGM 患者和 50 名健康志愿者女性。 : IGM 与 BC 患者在纤维蛋白原、纤维蛋白原/白蛋白（Fib/Alb）比值、C 反应蛋白（CRP）、白细胞（WBC）、中性粒细胞、中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和单核细胞值方面存在统计学显著差异。当纤维蛋白原（<0.001）、Fib/Alb 比值（<0.001）、CRP（<0.001）、WBC（<0.001）、中性粒细胞（<0.001）、NLR（<0.001）、单核细胞（=0.008）和 2 小时沉降率（<0.001）在各组之间进行比较时，IGM 组的水平最高。CRP 与白蛋白呈负相关，与 WBC、NLR、PLR 和 2 小时沉降率呈正相关。CRP 的灵敏度最高（95%），而 Fib/Alb 比值（86%）的特异性最高。与非复发性患者相比，复发性 IGM 患者的纤维蛋白原、Fib/Alb、CRP、中性粒细胞、NLR 和 2 小时红细胞沉降率（ESR）升高，淋巴细胞水平降低。 : 与 BC 相比，术前 CRP、白蛋白、纤维蛋白原、Fib/Alb、WBC、中性粒细胞、NLR、单核细胞和 2 小时 ESR 具有成为 IGM 炎症的早期和敏感生物标志物的巨大潜力。这些参数对疾病的复发也有显著影响，表明它们作为鉴别诊断 BC 与 IGM 的实用指南具有潜在应用价值。
