Aksan Hulya, Kundaktepe Berrin Papila, Sayili Ugurcan, Velidedeoglu Mehmet, Simsek Gonul, Koksal Selcuk, Gelisgen Remise, Yaylim Ilhan, Uzun Hafize
Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Haliç University, Istanbul, Turkey.
Biofactors. 2020 Nov;46(6):955-962. doi: 10.1002/biof.1676. Epub 2020 Sep 17.
This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). Forty-five patients with BC, 50 patients with IGM, and 48 healthy volunteers were included in the study. Serum miR-21 expression was significantly higher in BC (fold change = 2.42) and IGM group (fold change = 1.33) compared to control (p < .001). Serum miR-155 and let-7c expression levels were significantly lower in both groups compared to the control group (p < .001). miR-21 expression in BC was significantly higher than IGM (fold change = 1.976; p < .001). PTEN levels in BC were significantly higher than IGM (p < .001) and significantly lower than the control group (p < .001); the IGM group was significantly lower than the control group (p < .001). In addition to radiological data, serum miR-21 and PTEN levels may be noninvasive biomarkers that can help differentiate IGM from BC. The results of the study will lead to future studies in the differential diagnosis of IGM and BC.
本研究调查循环中的miR-155、let-7c、miR-21和PTEN水平是否可用于特发性肉芽肿性乳腺炎（IGM）和乳腺癌（BC）患者的鉴别诊断。45例乳腺癌患者、50例特发性肉芽肿性乳腺炎患者和48名健康志愿者纳入本研究。与对照组相比，乳腺癌组（倍数变化=2.42）和特发性肉芽肿性乳腺炎组（倍数变化=1.33）的血清miR-21表达显著更高（p < .001）。与对照组相比，两组的血清miR-155和let-7c表达水平均显著更低（p < .001）。乳腺癌中的miR-21表达显著高于特发性肉芽肿性乳腺炎（倍数变化=1.976；p < .001）。乳腺癌中的PTEN水平显著高于特发性肉芽肿性乳腺炎（p < .001），且显著低于对照组（p < .001）；特发性肉芽肿性乳腺炎组显著低于对照组（p < .001）。除放射学数据外，血清miR-21和PTEN水平可能是有助于鉴别特发性肉芽肿性乳腺炎和乳腺癌的非侵入性生物标志物。本研究结果将为特发性肉芽肿性乳腺炎和乳腺癌的鉴别诊断带来未来的研究方向。
