Furfaro Federica, Dal Buono Arianna, Allocca Mariangela, D'Amico Ferdinando, Zilli Alessandra, Gabbiadini Roberto, Danese Silvio
IBD Center, Humanitas Research Hospital-IRCCS, 20089 Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
Life (Basel). 2021 Jul 4;11(7):649. doi: 10.3390/life11070649.
Bowel ultrasound (BUS) is a non-invasive and accurate technique for assessing activity, extension of disease, and complications in inflammatory bowel diseases. The main advantages of BUS are its safety, reproducibility, and low costs. Ancillary technologies of BUS (i.e., color Doppler and wave elastography) could broaden the diagnostic power of BUS, allowing one to distinguish between inflammation and fibrosis. Considering the costs and invasiveness of colonoscopy and magnetic resonance, BUS appears as a fast, safe, and accurate technique. The objective measures of disease allow one to make clinical decisions, such as optimization, switch, or swap of therapy. Previous studies reported a sensitivity and a specificity of more than 90% compared to endoscopy and magnetic resonance. Lastly, transperineal ultrasound (TPUS) is a promising approach for the evaluation of perianal disease in Crohn's disease (CD) and disease activity in patients with ulcerative proctitis or pouchitis. Bowel ultrasound is being incorporated in the algorithm of managing inflammatory bowel diseases. Transmural healing evaluated through ultrasonography is emerging as a complementary target for disease treatment. In this review, we aimed to summarize and discuss the current evidence on BUS in the management of inflammatory bowel diseases and to address the challenges of a full validation of this technique.
肠道超声（BUS）是一种用于评估炎症性肠病的活动度、疾病范围及并发症的非侵入性准确技术。BUS的主要优点是安全性高、可重复性强且成本低。BUS的辅助技术（即彩色多普勒和弹性成像）可增强其诊断能力，使人们能够区分炎症和纤维化。考虑到结肠镜检查和磁共振成像的成本及侵入性，BUS是一种快速、安全且准确的技术。疾病的客观测量有助于做出临床决策，如优化、更换或调整治疗方案。先前的研究表明，与内镜检查和磁共振成像相比，其敏感性和特异性均超过90%。最后，经会阴超声（TPUS）是评估克罗恩病（CD）肛周疾病以及溃疡性直肠炎或储袋炎患者疾病活动度的一种有前景的方法。肠道超声正被纳入炎症性肠病的管理流程中。通过超声评估的透壁愈合正成为疾病治疗的一个补充靶点。在本综述中，我们旨在总结和讨论目前关于BUS在炎症性肠病管理中的证据，并探讨该技术全面验证面临的挑战。
