他汀类药物对肾素-血管紧张素系统的影响。

Kiaie Nasim, Gorabi Armita Mahdavi, Reiner Željko, Jamialahmadi Tannaz, Ruscica Massimiliano, Sahebkar Amirhossein

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.

Department of Internal Diseases, School of Medicine, University Hospital Center Zagreb, Zagreb University, 10000 Zagreb, Croatia.

J Cardiovasc Dev Dis. 2021 Jul 9;8(7):80. doi: 10.3390/jcdd8070080.

Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin-angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.

他汀类药物是一类用于降低血清低密度脂蛋白胆固醇的药物，因其广泛的多效性作用而受到关注。他汀类药物一个重要但常被忽视的作用是它们在肾素-血管紧张素系统（RAS）途径中的作用。该途径在包括高血压、心力衰竭和肾脏疾病在内的多种疾病进展中起着不可或缺的作用。本文综述了他汀类药物在阻断该途径不同成分中的作用及其潜在机制，并提出了他汀类药物新的治疗可能性。