使用BHN(CH)作为还原剂，通过酮/醛与胺进行还原胺化反应。

Reductive amination of ketones/aldehydes with amines using BHN(CH) as a reductant.

作者信息

Zou Qizhuang, Liu Fei, Zhao Tianxiang, Hu Xingbang

机构信息

Key Laboratory of Green Chemical and Clean Energy Technology, School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, P. R. China.

出版信息

Chem Commun (Camb). 2021 Sep 7;57(69):8588-8591. doi: 10.1039/d1cc02618f. Epub 2021 Aug 6.

DOI:10.1039/d1cc02618f

PMID:34357367

Abstract

Herein, we report the first example of efficient reductive amination of ketones/aldehydes with amines using BHN(CH) as a catalyst and a reductant under mild conditions, affording various tertiary and secondary amines in excellent yields. A mechanistic study indicates that BHN(CH) plays a dual function role of promoting imine and iminium formation and serving as a reductant in reductive amination.

摘要

在此，我们报道了首例在温和条件下使用BHN(CH)作为催化剂和还原剂，实现酮/醛与胺的高效还原胺化反应，以优异的产率得到各种叔胺和仲胺。机理研究表明，BHN(CH)在还原胺化反应中发挥促进亚胺和亚胺鎓形成以及作为还原剂的双重作用。