Wei Duo, Bruneau-Voisine Antoine, Valyaev Dmitry A, Lugan Noël, Sortais Jean-Baptiste
Univ Rennes, CNRS, ISCR - UMR 6226, F-35000, Rennes, France.
Chem Commun (Camb). 2018 Apr 24;54(34):4302-4305. doi: 10.1039/c8cc01787e.
A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 °C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.
开发了一种一锅两步法，用于在锰吡啶基膦配合物作为预催化剂存在下，以分子氢作为还原剂，通过醛的还原胺化反应实现胺的烷基化。在初始缩合步骤之后，原位形成的亚胺在温和条件（50-100℃）下，使用2 mol%的催化剂和5 mol%的叔丁醇钾，在50巴氢气压力下进行还原。对于大量的醛和胺组合（40个例子），包括脂肪醛和氨基醇，都获得了优异的产率（>90%）。
