Kleisbauer J P, Lena-Nosny N, Vesco D
Hôpital Salvator, Marseille, France.
Bull Cancer. 1987;74(6):631-4.
Seric values have been evaluated in 24 patients receiving high doses of etoposide. In 6 patients, CNS value was evaluated simultaneously. After 2 perfusions with 250 mg/m2 at 12 h interval, seric value is 35.3 micrograms/ml + 10.3, the value after 6 perfusions is 31.1 micrograms/ml + 6.5. The variation of CNS value observed from 0.08 to 0.49 micrograms/ml is 0.36 to 1.29% of the seric value; there is no positive correlation with seric value. Only one patient out of 6 has a partial response of CNS metastases.
已对24例接受高剂量依托泊苷治疗的患者的血清值进行了评估。其中6例患者同时评估了中枢神经系统值。在以12小时间隔进行2次250mg/m²的灌注后，血清值为35.3微克/毫升±10.3，6次灌注后的血清值为31.1微克/毫升±6.5。观察到的中枢神经系统值从0.08微克/毫升至0.49微克/毫升的变化为血清值的0.36%至1.29%；与血清值无正相关。6例患者中只有1例对中枢神经系统转移有部分反应。
