Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
J Oral Pathol Med. 2022 Jan;51(1):18-29. doi: 10.1111/jop.13225. Epub 2021 Aug 16.
The essential role HOX-associated non-coding RNAs play in chromatin dynamics and gene regulation has been well documented. The potential roles of these microRNAs and long non-coding RNAs in oral cancer development, with their attendant involvement in various cellular processes including proliferation, invasion, migration, epithelial-mesenchymal transition and metastasis is gaining credence. An interaction network of HOX-embedded non-coding RNAs was constructed to identify the RNA interaction landscape using the arena-Idb platform and visualized using Cytoscape. The miR-10a was shown to interact with HOXA1, miR-10b with HOXD10, miR-196a1 with HOXA5, HOXA7, HOXB8, HOXC8, HOXD8, and miR-196a2 with HOXA5. The lncRNAs, HOTAIR interacted with HOXC11, HOTAIRM1 with HOXA1 and HOXA4, HOTTIP with HOXA13, HOXA-AS2 with HOXA3, HOXA11-AS with HOXA11 and HOXD-AS1 with HOXB8. Changes in the HOX cluster-embedded non-coding RNAs have implications for prognosis and overall disease survival. Our review aims to analyze the functional significance and clinical relevance of non-coding RNAs within the HOX cluster in the context of oral carcinogenesis. Elucidating these interactions between the non-coding RNAs and HOX genes in oral cancer development and progression could pave the way for the identification of reliable biomarkers and potential therapeutic targets.
HOX 相关非编码 RNA 在染色质动力学和基因调控中发挥的重要作用已得到充分证实。这些 microRNA 和长非编码 RNA 在口腔癌发展中的潜在作用，以及它们在包括增殖、侵袭、迁移、上皮-间充质转化和转移在内的各种细胞过程中的参与，正越来越受到关注。利用 arena-Idb 平台构建了 HOX 嵌入非编码 RNA 的相互作用网络，以识别 RNA 相互作用图谱，并使用 Cytoscape 可视化。结果表明，miR-10a 与 HOXA1 相互作用，miR-10b 与 HOXD10 相互作用，miR-196a1 与 HOXA5、HOXA7、HOXB8、HOXC8、HOXD8 相互作用，miR-196a2 与 HOXA5 相互作用。lncRNA，HOTAIR 与 HOXC11 相互作用，HOTAIRM1 与 HOXA1 和 HOXA4 相互作用，HOTTIP 与 HOXA13 相互作用，HOXA-AS2 与 HOXA3 相互作用，HOXA11-AS 与 HOXA11 相互作用，HOXD-AS1 与 HOXB8 相互作用。HOX 簇嵌入非编码 RNA 的变化对预后和整体疾病生存有影响。我们的综述旨在分析 HOX 簇内非编码 RNA 在口腔癌发生中的功能意义和临床相关性。阐明这些非编码 RNA 与 HOX 基因在口腔癌发生和发展中的相互作用，可能为识别可靠的生物标志物和潜在的治疗靶点铺平道路。
