展开、结合、绑定、易位：细菌蛋白易位的多层次动力学。

Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation.

机构信息

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.

出版信息

Structure. 2021 Aug 5;29(8):781-782. doi: 10.1016/j.str.2021.07.003.

DOI:10.1016/j.str.2021.07.003

Abstract

The bacterial Sec translocase transports unfolded proteins across membranes. In this issue of Structure, Krishnamurthy et al. (2021) report a nexus of conformational dynamics in the translocase motor protein, SecA. Their findings shed light on the Sec activation mechanism and suggest a general role for multi-level dynamics in protein functions.

摘要

细菌 Sec 转运蛋白将未折叠的蛋白质穿过膜运输。在本期《结构》中，Krishnamurthy 等人（2021 年）报道了 SecA 转运蛋白马达中构象动力学的连接点。他们的发现揭示了 Sec 激活机制，并暗示了多层次动力学在蛋白质功能中的普遍作用。