Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
Department of Psychology, Tufts University, Medford, MA, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jan 10;112:110422. doi: 10.1016/j.pnpbp.2021.110422. Epub 2021 Aug 4.
Inflammation is involved in the pathogenesis of psychiatric disorders. Many previous studies have defined the important roles of inflammatory factors in the pathogenesis, diagnosis, and treatment outcomes of psychiatric disorders. Macrophage migration inhibitory factor (MIF), a pro-inflammatory factor, has been gradually recognized to be involved in the development of neurological diseases in recent years. Our current review focuses on discussing the potential beneficial and detrimental roles of MIF in psychiatric disorders. We will provide new mechanistic insights for the development of potential diagnostic and therapeutic biomarkers based on MIF for psychiatric diseases.
炎症参与了精神疾病的发病机制。许多先前的研究已经确定了炎症因子在精神疾病的发病机制、诊断和治疗结果中的重要作用。巨噬细胞移动抑制因子（MIF）是一种促炎因子，近年来逐渐被认为与神经疾病的发展有关。我们目前的综述重点讨论了 MIF 在精神疾病中的潜在有益和有害作用。我们将根据 MIF 为精神疾病提供新的潜在诊断和治疗生物标志物的发展提供新的机制见解。
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