Zhu Wen-Qian, Wu Hui-Ying, Sun Zhi-Hui, Guo Yi, Ge Tong-Tong, Li Bing-Jin, Li Xin, Cui Ran-Ji
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China.
Department of Pharmacy, The Eastern Division of First Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2022 May 23;13:824420. doi: 10.3389/fphar.2022.824420. eCollection 2022.
A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.
抑郁症是一种主要的严重情绪障碍，目前是一种广泛存在且容易被忽视的心理疾病。随着天然产物在疾病治疗中副作用低成为新型抗抑郁药的追求目标，天然中药产品因其在改善抑郁症方面的独特功效而受到越来越多的关注。从目前的研究来看，黄连素的积极抗抑郁作用令人鼓舞。要准确阐明黄连素在抑郁症中的疗效和机制，还有很多工作要做。在这篇综述中，更新了黄连素治疗抑郁症和焦虑症的相关文献报道，并探讨了黄连素缓解抑郁症的潜在药理机制。
