University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ophthalmology Department, Ankara, Turkey.
University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ophthalmology Department, Ankara, Turkey.
Photodiagnosis Photodyn Ther. 2021 Sep;35:102475. doi: 10.1016/j.pdpdt.2021.102475. Epub 2021 Aug 3.
The aim of this study was to evaluate potential changes in choroidal flow in patients with newly diagnosed obsessive-compulsive disorder based on optical coherence tomography angiography findings and to investigate the relationship between subfoveal choroidal thickness and choriocapillaris flow area.
This prospective study included newly diagnosed obsessive-compulsive disorder patients and healthy controls. All patients underwent enhanced depth imaging-optical coherence tomography imaging to assess the subfoveal choroidal thickness and optical coherence tomography angiography imaging to evaluate the choriocapillaris flow area.
A total of 55 patients with obsessive-compulsive disorder and 50 controls were included. The mean subfoveal choroidal thickness was significantly greater in the obsessive-compulsive disorder group compared to the control group (p˂0.001). Regarding the choriocapillaris flow area, the values for area with a radius of 1 mm, 2 mm and 3 mm were significantly lower in the obsessive-compulsive disorder group than in the control group (p=0.019, p=0.014, and p=0.004, respectively). There was a significant negative correlation between subfoveal choroidal thickness and choriocapillaris flow area with a radius of 1mm (r=-0.387, p=0.024).
Choroidal changes in obsessive-compulsive disorder patients suggest the choroidal features of uncomplicated pachychoroid. Obsessive-compulsive disorder may be prone to a spectrum of conditions characterized by pachychoroid features.
本研究旨在通过光相干断层扫描血管造影（OCTA）评估初诊强迫症患者脉络膜血流的潜在变化，并探讨中心凹下脉络膜厚度（subfoveal choroidal thickness，SFCT）与脉络膜毛细血管血流面积之间的关系。
本前瞻性研究纳入了初诊强迫症患者和健康对照者。所有患者均行增强深度成像 OCT 以评估中心凹下脉络膜厚度，行 OCTA 以评估脉络膜毛细血管血流面积。
共纳入 55 例强迫症患者和 50 例对照者。强迫症组的 SFCT 显著大于对照组（p＜0.001）。在脉络膜毛细血管血流面积方面，1mm、2mm 和 3mm 半径的区域面积值在强迫症组显著低于对照组（p=0.019、p=0.014 和 p=0.004）。SFCT 与 1mm 半径的脉络膜毛细血管血流面积呈显著负相关（r=-0.387，p=0.024）。
强迫症患者的脉络膜改变提示存在脉络膜增厚特征。强迫症可能是一种以脉络膜增厚特征为特征的疾病谱。
