Ibrahim M S, Maged Z A, Haron A, Khalil R Y, Attallah A M
Department of Microbiology and Immunology, Ain Shams Faculty of Medicine, Cairo, Egypt.
Chemioterapia. 1987 Dec;6(6):426-30.
We studied the effects of antibiotics on natural killer (NK), antibody dependent cell-mediated cytotoxicity (ADCC) and immunoglobulin production. When human peripheral blood lymphocytes were incubated overnight with the antibiotic before the assay, nitrofurantoin significantly reduced NK but not ADCC activity. Nitrofurantoin also suppressed both spontaneous and interferon-enhanced NK activities in a dose-dependent fashion. Though it did not affect spontaneous ADCC activity, nitrofurantoin suppressed interferon enhancement of ADCC. Chloramphenicol significantly decreased the number of plaque forming cells in mice. In addition to chloramphenicol, tetracycline, rifampicin, cephalothin, polymyxin B and nitrofurantoin reduced mitogen-induced polycloned immunoglobulin synthesis. Results of this study may have clinical relevance, especially in treating immunocompromised patients.
我们研究了抗生素对自然杀伤细胞（NK）、抗体依赖性细胞介导的细胞毒性（ADCC）和免疫球蛋白产生的影响。在检测前，将人外周血淋巴细胞与抗生素孵育过夜，呋喃妥因显著降低了NK活性，但未影响ADCC活性。呋喃妥因还以剂量依赖性方式抑制自发和干扰素增强的NK活性。虽然它不影响自发的ADCC活性，但呋喃妥因抑制了干扰素对ADCC的增强作用。氯霉素显著减少了小鼠中形成噬斑细胞的数量。除氯霉素外，四环素、利福平、头孢菌素、多粘菌素B和呋喃妥因也降低了丝裂原诱导的多克隆免疫球蛋白合成。本研究结果可能具有临床相关性，特别是在治疗免疫功能低下的患者时。
