Gravagna P, Gianazza E, Arnaud P, Neels M, Ades E W
J Reticuloendothel Soc. 1982 Aug;32(2):125-30.
The effects of alpha 1-antichymotrypsin (AChy), a serum protease inhibitor, on two parameters of the cellular immune response, natural killing (NK) and antibody-dependent cell-mediated cytotoxicity (ADCC), were tested. Both NK and ADCC were inhibited by the protein in a dose-dependent fashion. Our results suggest that this protease inhibitor binds to the surface of NK and ADCC target cells and neutralizes the lytic signal passed between the effector and target.
血清蛋白酶抑制剂α1-抗糜蛋白酶（AChy）对细胞免疫反应的两个参数，即自然杀伤（NK）和抗体依赖性细胞介导的细胞毒性（ADCC）的影响进行了测试。蛋白质以剂量依赖的方式抑制NK和ADCC。我们的结果表明，这种蛋白酶抑制剂与NK和ADCC靶细胞表面结合，并中和效应细胞和靶细胞之间传递的裂解信号。
