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18F-氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描（F-FDG PET/CT）与诊断性增强CT用于接受免疫检查点抑制剂治疗的IV期黑色素瘤患者随访：一所大学医院3年期间不一致情况的发生率及处理

F-FDG PET/CT versus Diagnostic Contrast-Enhanced CT for Follow-Up of Stage IV Melanoma Patients Treated by Immune Checkpoint Inhibitors: Frequency and Management of Discordances over a 3-Year Period in a University Hospital.

作者信息

Le Goubey Jean-Baptiste, Lasnon Charline, Nakouri Ines, Césaire Laure, de Pontville Michel, Nganoa Catherine, Kottler Diane, Aide Nicolas

机构信息

Dermatology Department, University Hospital, 14000 Caen, France.

Nuclear Medicine Department, François Baclesse Cancer Centre, 14000 Caen, France.

出版信息

Diagnostics (Basel). 2021 Jul 1;11(7):1198. doi: 10.3390/diagnostics11071198.

DOI:10.3390/diagnostics11071198
PMID:34359281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8304093/
Abstract

AIM

To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma.

MATERIALS AND METHODS

We conducted a retrospective monocentric observational study over a 3-year period in patients referred for F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus. The anatomical site responsible for discordances, as well as induced changes in treatment were noted.

RESULTS

Eighty patients were included and 195 pairs of scans analyzed. Overall, discordances occurred in 65 cases (33%). Eighty percent of the discordances (52/65) were due to F-FDG PET/CT scans upstaging the patient. Amongst these discordances, 17/52 (33%) led to change in patient's management, the most frequent being radiotherapy of a progressing site. ceCT represented 13/65 (20%) of discordances and induced changes in patients' management in 2/13 cases (15%). The most frequent anatomical site involved was subcutaneous for F-FDG PET/CT findings and lung or liver for ceCT.

CONCLUSIONS

Treatment monitoring with F-FDG PET/CT is more efficient than ceCT and has a greater impact in patient's management.

摘要

目的

对对比增强CT（ceCT）与F-FDG PET/CT在评估IV期黑色素瘤患者脑外治疗监测中的不一致性进行全面分析。

材料与方法

我们在2017年1月起的3年期间，对因免疫检查点抑制剂（ICIs）治疗监测而接受F-FDG PET/CT和ceCT检查的患者进行了一项回顾性单中心观察性研究。影像报告由两位医生共同分析。记录导致不一致的解剖部位以及治疗中发生的变化。

结果

纳入80例患者，分析了195对扫描结果。总体而言，65例（33%）出现不一致情况。80%的不一致情况（52/65）是由于F-FDG PET/CT扫描将患者分期提高。在这些不一致情况中，17/52（33%）导致患者治疗方案改变，最常见的是对进展部位进行放疗。ceCT占不一致情况的13/65（20%），并在2/13例（15%）中导致患者治疗方案改变。F-FDG PET/CT发现的最常见受累解剖部位是皮下，而ceCT发现的是肺或肝。

结论

使用F-FDG PET/CT进行治疗监测比ceCT更有效，对患者治疗方案的影响更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/a54537cc8dd2/diagnostics-11-01198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/2353834f0328/diagnostics-11-01198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/0cda8f722062/diagnostics-11-01198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/1adb1ce24488/diagnostics-11-01198-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/8d2a7ee56ec2/diagnostics-11-01198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/90c5fdba7138/diagnostics-11-01198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/9b5bb8f8f941/diagnostics-11-01198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/1b661c7178e3/diagnostics-11-01198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/a54537cc8dd2/diagnostics-11-01198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/2353834f0328/diagnostics-11-01198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/0cda8f722062/diagnostics-11-01198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/1adb1ce24488/diagnostics-11-01198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/c409e75059a4/diagnostics-11-01198-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/8d2a7ee56ec2/diagnostics-11-01198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/90c5fdba7138/diagnostics-11-01198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/9b5bb8f8f941/diagnostics-11-01198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/1b661c7178e3/diagnostics-11-01198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2977/8304093/a54537cc8dd2/diagnostics-11-01198-g009.jpg

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本文引用的文献

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Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2573-2585. doi: 10.1007/s00259-020-05103-3. Epub 2021 Jan 12.
2
Digital versus analog PET/CT in patients with known or suspected liver metastases.数字 PET/CT 与模拟 PET/CT 在已知或疑似肝转移患者中的比较。
Nucl Med Commun. 2021 Apr 1;42(4):421-428. doi: 10.1097/MNM.0000000000001341.
3
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Eur Urol Focus. 2021 Sep;7(5):1092-1099. doi: 10.1016/j.euf.2020.10.003. Epub 2020 Nov 7.
4
Impact of scanner harmonization on PET-based treatment response assessment in metastatic melanoma.基于正电子发射断层扫描（PET）扫描仪的标准化对转移性黑色素瘤治疗反应评估的影响。
Phys Med Biol. 2020 Dec 7;65(22):225003. doi: 10.1088/1361-6560/abb6bb.
5
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