Centre François Baclesse, Nuclear Medicine Department, Caen, France; INSERM ANTICIPE, Normandie University, Caen, France.
CHU de Caen, Nuclear Medicine Department, Caen, France.
Eur J Radiol. 2020 Aug;129:109144. doi: 10.1016/j.ejrad.2020.109144. Epub 2020 Jun 20.
To seek for the minimal duration per bed position with a digital PET system without compromising image quality and lesion detection in patients requiring fast F-FDG PET imaging.
19 cancer patients experiencing pain or dyspnea and 9 pediatric patients were scanned on a Vereos system. List mode data were reconstructed with decreasing time frame down to 10 s per bed position. Noise was evaluated in the liver, blood pool and muscle, and using target-to-background ratios. Five PET readers recorded image quality, number of clinically relevant foci and of involved anatomical sites in reconstructions ranging from 60 to 10 s per bed position, compared to the standard 90 s reconstruction.
The following reconstructions, which harboured a noise not significantly higher than that of the standard reconstruction, were selected for clinical evaluation: 1iterations/10 subsets/20 (1i10 s20), 1i10 s30, and 2i10 sPSF60 Only the 60 s per bed acquisition displayed similar target-to-background ratios compared to the standard reconstruction, but mean ratios were still higher than 2.0 for the 30 s reconstruction. Inter-rater agreement for the number of involved anatomical sites and detected lesion was good or almost perfect (Kappa: 0.64-0.91) for all acquisitions. In particular, kappa for the 30 s per bed acquisition was 0.78 and 0.91 for lesion and anatomical sites number, respectively. Intra-rater agreement was also excellent for the 30 s reconstruction (kappa = 0.72). Median estimated total PET acquisition time for the 1i10 s30, and the standard reconstruction were 4 and 12 min, respectively.
Fast imaging is feasible with state-of-the-art PET systems. Acquisitions of 30 s per bed position are feasible with the Vereos system, requiring optimization of reconstruction parameters.
在不影响图像质量和病灶检出率的情况下，为需要快速 F-FDG PET 成像的患者寻找最小床位位置时长的数字 PET 系统。
19 名癌症患者因疼痛或呼吸困难，9 名儿科患者在 Vereos 系统上进行扫描。使用降低时间框架的方法，将列表模式数据重建为每个床位位置 10 秒。在肝脏、血池和肌肉中评估噪声，并使用目标与背景的比值。5 位 PET 读者记录图像质量、重建中每个床位位置从 60 秒到 10 秒的临床相关病灶数量和受累解剖部位数量，并与标准的 90 秒重建进行比较。
选择以下重建方案进行临床评估，这些方案的噪声与标准重建没有显著差异：1 次迭代/10 个子集/20（1i10s20）、1i10s30 和 2i10sPSF60。只有 60 秒的床位采集与标准重建相比显示出相似的目标与背景比值，但 30 秒重建的平均比值仍高于 2.0。对于所有采集，病变和受累解剖部位数量的观察者间一致性良好或几乎完美（kappa：0.64-0.91）。特别是，30 秒采集的 kappa 值分别为 0.78 和 0.91。30 秒重建的观察者内一致性也很好（kappa = 0.72）。1i10s30 和标准重建的中位总 PET 采集时间分别为 4 分钟和 12 分钟。
使用最先进的 PET 系统可以实现快速成像。在 Vereos 系统上，每个床位位置 30 秒的采集是可行的，需要优化重建参数。
