Nishikawa Hiroki, Yoh Kazunori, Enomoto Hirayuki, Nishiguchi Shuhei, Iijima Hiroko
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
Diagnostics (Basel). 2021 Jul 14;11(7):1262. doi: 10.3390/diagnostics11071262.
We aimed to examine the association between sarcopenia-related factors and metabolic syndrome (Met-S) in patients with chronic liver diseases (CLDs, n = 582, average age = 59.5 years, 290 males, 168 liver cirrhosis cases). Met-S was determined based on the Japanese criteria. Sarcopenia was determined based on grip strength (GS) and skeletal muscle index (SMI) by bioelectrical impedance analysis. Our cohort was divided into the four groups: (A) sarcopenia (n = 44), (B) dynapenia (n = 45), (C) presarcopenia (n = 112), and (D) the control (n = 381). Impacts of GS and SMI on Met-S were investigated. In males, waist circumference (WC) ≥ 85 cm was observed in 199 patients (68.6%), while in females, WC ≥ 90 cm was observed in 94 patients (32.2%). Met-S was identified in 109 patients (18.7%). The proportion of Met-S in the group A, B, C and D were 18.2%, 48.9%, 8.0%, and 18.4% (A vs. B, = 0.0033; B vs. C, < 0.0001; C vs. D, = 0.0081; A vs. C, = 0.0867; A vs. D, = 1.000, B vs. D, < 0.0001; overall value < 0.0001). Multivariate analysis revealed that age, gender, and group B (dynapenia) were significant factors linked to the presence of Met-S. In conclusion, dynapenia rather than sarcopenia is associated with Met-S in CLD patients.
我们旨在研究慢性肝病（CLD，n = 582，平均年龄 = 59.5岁，男性290例，肝硬化病例168例）患者中肌肉减少症相关因素与代谢综合征（Met-S）之间的关联。Met-S根据日本标准确定。肌肉减少症通过生物电阻抗分析，依据握力（GS）和骨骼肌指数（SMI）来确定。我们的队列分为四组：（A）肌肉减少症组（n = 44），（B）肌力减退组（n = 45），（C）肌肉减少症前期组（n = 112），以及（D）对照组（n = 381）。研究了GS和SMI对Met-S的影响。在男性中，199例患者（68.6%）腰围（WC）≥85 cm，而在女性中，94例患者（32.2%）腰围≥90 cm。109例患者（18.7%）被诊断为Met-S。A、B、C和D组中Met-S的比例分别为18.2%、48.9%、8.0%和18.4%（A组与B组，P = 0.0033；B组与C组，P < 0.0001；C组与D组，P = 0.0081；A组与C组，P = 0.0867；A组与D组，P = 1.000，B组与D组，P < 0.0001；总体P值< 0.0001）。多变量分析显示，年龄、性别和B组（肌力减退）是与Met-S存在相关的显著因素。总之，在CLD患者中，与Met-S相关的是肌力减退而非肌肉减少症。
