Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Aging (Albany NY). 2021 Feb 26;13(5):7247-7258. doi: 10.18632/aging.202581.
Low muscle function determined unfavorable clinical outcome than low muscle mass; nevertheless, comparison of detrimental parameters among dynapenia, presarcopenia and sarcopenia was sparse. We hypothesized that adiposity is implicated in low muscle function related adverse events.
We recruited community elders to measure handgrip strength and walking speed. Using bioelectronics impedance analyzer to examine body compositions. The faller is indicated of having a fall event in the past one year. Associations of different obesity parameters, metabolic syndrome (MetS) and fall among the groups were analyzed.
Among 765 participants, the dynapenia group had higher metabolic profiles, body fat percentage (BFP), waist circumference, and fat to muscle ratio (FMR) than the other groups, whereas the presarcopenia subjects had the lowest obesity parameters. The fallers tended to have poorer muscle function than non-fallers (p<0.001). The dynapenia individuals had the highest risk for MetS (odds ratio [OR]= 5.79; 95% confidence interval [CI]= 2.45-13.73), and the highest fall risk (OR= 3.11; 95% CI=1.41-6.87). Among obesity parameters, FMR had better diagnostic performance to estimate low muscle function, followed by BFP.
Dynapenia individual had higher risk of obese-related adverse events. Increased adiposity irrespective of muscle mass is relevant to reduced muscle function among elders.
肌肉功能低下比肌肉量减少更能预示不良的临床结局；然而，关于肌无力、少肌症和肌少症之间的有害参数的比较却很少。我们假设肥胖与肌肉功能低下相关的不良事件有关。
我们招募了社区老年人来测量握力和步行速度。使用生物电阻抗分析仪检查身体成分。在过去一年中有跌倒事件的人被定义为跌倒者。分析不同肥胖参数、代谢综合征（MetS）和各组之间跌倒之间的关系。
在 765 名参与者中，肌无力组的代谢指标、体脂肪百分比（BFP）、腰围和脂肪与肌肉比率（FMR）均高于其他组，而少肌症组的肥胖参数最低。与非跌倒者相比，跌倒者的肌肉功能更差（p<0.001）。肌无力个体患代谢综合征的风险最高（比值比[OR]=5.79；95%置信区间[CI]=2.45-13.73），跌倒风险最高（OR=3.11；95% CI=1.41-6.87）。在肥胖参数中，FMR 对估计肌肉功能低下的诊断性能更好，其次是 BFP。
肌无力个体患肥胖相关不良事件的风险更高。老年人中，无论肌肉量如何增加，脂肪增加都与肌肉功能下降有关。
