Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Faculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.
Cells. 2021 Jul 8;10(7):1722. doi: 10.3390/cells10071722.
Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.
流感是一种具有重大公共卫生意义的人畜共患呼吸道疾病，因其具有大流行的潜力，对动物和人类构成威胁。甲型流感病毒基因组由八个单链 RNA 片段组成，这些片段被包裹在蛋白质衣壳和脂质双层包膜内。在宿主细胞进入过程中，细胞信号促进了病毒构象的变化，从而促进了关键事件的发生，如与晚期内体融合、衣壳脱壳以及病毒基因组释放到细胞质中。在本篇重点综述中，我们简要描述了病毒感染周期，并强调了宿主细胞通路和细胞质蛋白在协助流感病毒进入宿主细胞时进行衣壳脱壳的最新发现。
