Department of Biomedical Sciences, Graduate School, Seoul National University, Seoul 03080, Korea.
Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Int J Environ Res Public Health. 2021 Jul 28;18(15):7996. doi: 10.3390/ijerph18157996.
The association of short-term particulate matter concentration with cardiovascular disease (CVD) among cancer survivors is yet unclear. Using the National Health Insurance Service database from South Korea, the study population consisted of 22,864 5-year cancer survivors with CVD events during the period 2015-2018. Using a time-stratified case-crossover design, each case date (date of incident CVD) was matched with three or four referent dates, resulting in a total of 101,576 case and referent dates. The daily average particulate matter 10 (PM10), 2.5 (PM2.5), and 2.5-10 (PM2.5-10) on the day of case or referent date (lag0), 1-3 days before the case or referent date (lag1, lag2, and lag3), and the mean value 0-3 days before the case or referent date (lag0-3) were determined. Conditional logistic regression was conducted to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for CVD according to quartiles of PM10, PM2.5, and PM2.5-10. Compared to the 1st (lowest) quartile of lag0-3 PM10, the 4th (highest) quartile of lag0-3 PM10 was associated with higher odds for CVD (aOR 1.13, 95% CI 1.06-1.21). The 4th quartiles of lag1 (aOR 1.12, 95% CI 1.06-1.19), lag2 (aOR 1.09, 95% CI 1.03-1.16), lag3 (aOR 1.06, 95% CI 1.00-1.12), and lag0-3 (aOR 1.11, 95% CI 1.05-1.18) PM2.5 were associated with higher odds for CVD compared to the respective 1st quartiles. Similarly, the 4th quartile of lag0-3 PM2.5-10 was associated with higher CVD events (aOR 1.11, 95% CI 1.03-1.19) compared to the 1st quartile. Short-term exposure to high levels of PM may be associated with increased CVD risk among cancer survivors.
短期颗粒物浓度与癌症幸存者心血管疾病（CVD）之间的关联尚不清楚。本研究使用了来自韩国的国家健康保险服务数据库，研究人群包括 2015 年至 2018 年期间患有 CVD 事件的 22864 名 5 年癌症幸存者。采用时间分层病例交叉设计，每个病例日期（CVD 事件发生日期）与三个或四个参照日期相匹配，总共产生了 101576 个病例和参照日期。在病例或参照日期当天（lag0）、病例或参照日期前 1-3 天（lag1、lag2 和 lag3）以及病例或参照日期前 0-3 天的平均水平（lag0-3）确定了每日平均颗粒物 10（PM10）、2.5（PM2.5）和 2.5-10（PM2.5-10）。采用条件逻辑回归计算了 PM10、PM2.5 和 PM2.5-10 四分位间距的 CVD 的调整优势比（aOR）和 95%置信区间（CI）。与 lag0-3PM10 的第 1 （最低）四分位相比，lag0-3PM10 的第 4 （最高）四分位与 CVD 的更高几率相关（aOR1.13，95%CI1.06-1.21）。与 lag1 的第 4 四分位（aOR1.12，95%CI1.06-1.19）、lag2（aOR1.09，95%CI1.03-1.16）、lag3（aOR1.06，95%CI1.00-1.12）和 lag0-3（aOR1.11，95%CI1.05-1.18）相比，PM2.5 更高。同样，与第 1 四分位相比，lag0-3PM2.5-10 的第 4 四分位与更高的 CVD 事件相关（aOR1.11，95%CI1.03-1.19）。短期暴露于高水平的 PM 可能与癌症幸存者 CVD 风险增加有关。
