Escuela Internacional de Doctorado, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, Spain.
Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, Spain.
Int J Environ Res Public Health. 2021 Jul 31;18(15):8138. doi: 10.3390/ijerph18158138.
Parkinson's disease (PD) is the most common neurodegenerative disorder associated with motor and nonmotor symptoms. Drooling, one of the nonmotor symptoms, can be present in 70-80% of patients with PD. The aim of this paper is to study the characteristics of PD patients with drooling compared to those without in terms of age, gender, disease duration, stage of the disease, swallowing difficulties, and health-related quality of life; methods: a cross-sectional study was conducted. The sample was divided into two groups: PD with drooling ( = 32) and PD without drooling ( = 30). Age, gender, disease duration and Hoehn & Yahr (H & Y) stage, Sialorrhea Clinical Scale for Parkinson's Disease (SCS-PD), the 10-item Eating Assessment Tool (EAT-10), and the 39-item Parkinson's Disease Questionnaire (PDQ-39) were compared between groups; Results: 62 individuals with PD, 40 men and 22 women (mean age 73 ± 8 years), were included. Overall, 32 patients reported drooling, and 30 did not exhibit it. The ANCOVA found significant differences between groups for the EAT-10 score (0.83, 95% CI = 5.62-9.03; = 0.016) and SCS-PD score (1.48, 95% CI = 0.86-6.81; < 0.001). Analysis of the PDQ-39 scores revealed no significant differences between groups for the PDQ-39 total score ( > 0.057) and in all subscales. The inclusion of gender, age, disease duration, and H & Y as covariates did not influence the results (all > 0.05).
drooling is related to swallowing difficulties assessed with EAT-10 but not with health-related quality of life assessed with PDQ-39 in PD patients with drooling compared to PD patients without it. Age, gender, duration of the disease, and the H & Y state of PD patients with and without drooling seem to be similar.
帕金森病（PD）是最常见的与运动和非运动症状相关的神经退行性疾病。流涎是一种非运动症状，可发生在 70-80%的 PD 患者中。本文旨在研究流涎 PD 患者与无流涎 PD 患者在年龄、性别、疾病持续时间、疾病阶段、吞咽困难和健康相关生活质量方面的特征；方法：进行了一项横断面研究。样本分为两组：流涎 PD 组（=32）和无流涎 PD 组（=30）。比较两组间年龄、性别、疾病持续时间和 Hoehn & Yahr（H & Y）分期、帕金森病流涎临床量表（SCS-PD）、10 项饮食评估工具（EAT-10）和 39 项帕金森病问卷（PDQ-39）；结果：共纳入 62 例 PD 患者，其中男性 40 例，女性 22 例（平均年龄 73±8 岁）。总体而言，32 例患者报告流涎，30 例患者无流涎。ANCOVA 发现两组 EAT-10 评分（0.83，95%CI=5.62-9.03；=0.016）和 SCS-PD 评分（1.48，95%CI=0.86-6.81；<0.001）存在显著差异。PDQ-39 评分分析显示，两组 PDQ-39 总分（>0.057）和各亚量表均无显著差异。将性别、年龄、疾病持续时间和 H & Y 作为协变量纳入后，结果无影响（均>0.05）。
与无流涎 PD 患者相比，流涎 PD 患者的流涎与 EAT-10 评估的吞咽困难相关，但与 PDQ-39 评估的健康相关生活质量无关。有流涎和无流涎的 PD 患者的年龄、性别、疾病持续时间和 H & Y 状态似乎相似。
