Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan.
Department of Optometry, Chung Shan Medical University, Taichung 402, Taiwan.
Int J Environ Res Public Health. 2021 Aug 1;18(15):8154. doi: 10.3390/ijerph18158154.
The purpose of this study is to evaluate the relationship between hydroxychloroquine (HCQ) and diabetic retinopathy (DR) via the national health insurance research database (NHIRD) of Taiwan. All patients with newly diagnosed type 2 diabetes ( = 47,353) in the NHIRD (2000-2012) were enrolled in the study. The case group consists of participants with diabetic ophthalmic complications; 1:1 matching by age (±1 year old), sex, and diagnosis year of diabetes was used to provide an index date for the control group that corresponded to the case group ( = 5550). Chi-square test for categorical variables and Student's t-test for continuous variables were used. Conditional logistic regression was performed to estimate the adjusted odds ratio (aOR) of DR. The total number of HCQ user was 99 patients (1.8%) in the case group and 93 patients (1.7%) in the control group. Patients with hypertension (aOR = 1.21, 95% CI = 1.11-1.31) and hyperlipidemia (aOR = 1.65, 95% CI = 1.52-1.79) significantly increased the risk of diabetic ophthalmic complications ( < 0.001). Conversely, the use of HCQ and the presence of rheumatoid diseases did not show any significance in increased risk of DR. HCQ prescription can improve systemic glycemic profile, but it does not decrease the risk of diabetic ophthalmic complications.
本研究旨在通过台湾全民健康保险研究数据库（NHIRD）评估羟氯喹（HCQ）与糖尿病视网膜病变（DR）之间的关系。NHIRD（2000-2012 年）中所有新诊断为 2 型糖尿病的患者（=47353）均纳入本研究。病例组由伴有糖尿病眼部并发症的参与者组成；通过年龄（±1 岁）、性别和糖尿病诊断年份对病例组进行 1:1 匹配，为对照组提供与病例组相对应的索引日期（=5550）。采用卡方检验对分类变量进行分析，采用学生 t 检验对连续变量进行分析。采用条件逻辑回归估计 DR 的调整比值比（aOR）。病例组中 HCQ 使用者总数为 99 例（1.8%），对照组中为 93 例（1.7%）。患有高血压（aOR=1.21，95%CI=1.11-1.31）和高血脂（aOR=1.65，95%CI=1.52-1.79）的患者发生糖尿病眼部并发症的风险显著增加（<0.001）。相反，HCQ 的使用和类风湿性疾病的存在并未显示出增加 DR 风险的任何意义。HCQ 处方可改善全身血糖状况，但不能降低糖尿病眼部并发症的风险。
