Lindenhayn K, Haupt R, Heilmann H H
Department of Orthopaedic Surgery, School of Medicine (Charité), Humboldt University, Berlin, GDR.
Clin Chim Acta. 1987 Nov 30;170(1):57-67. doi: 10.1016/0009-8981(87)90383-4.
A modified radial diffusion assay was used for the direct semiquantitative determination of low molecular mass trypsin inhibitors in small samples of human cartilage. The low molecular mass trypsin inhibitor in articular cartilage of normal human femoral heads is not distributed evenly but occurs in areas of low, medium and high content. The weight-bearing area of the femoral head belongs among the regions with low inhibitor content. The results obtained with osteoarthritic femoral heads showed that the inhibitor content in osteoarthritic cartilage is significantly lower than that in normal articular cartilage (p less than 0.1%).
采用改良的径向扩散试验对人软骨小样本中的低分子量胰蛋白酶抑制剂进行直接半定量测定。正常人股骨头关节软骨中的低分子量胰蛋白酶抑制剂分布不均，存在含量低、中、高的区域。股骨头的负重区属于抑制剂含量低的区域。骨关节炎股骨头的检测结果表明，骨关节炎软骨中的抑制剂含量明显低于正常关节软骨（p<0.1%）。
