Roberts S, Weightman B, Urban J, Chappell D
J Bone Joint Surg Br. 1986 Mar;68(2):278-88. doi: 10.1302/0301-620X.68B2.3958016.
We studied the mechanical and biochemical properties of articular cartilage from 22 osteoarthritic femoral heads obtained at operation and 97 femoral heads obtained at autopsy. Cartilage from the zenith and from the antero-inferior aspect of each head was tested both in tension and in compression. Water content, swelling ability and proteoglycan content were measured, the cartilage was examined histologically and the density of the underlying bone was assessed. Fifty-five of the autopsy specimens were defined as macroscopically normal because they exhibited no progressive fibrillation patterns on staining with Indian ink; but significant changes in water content, bone density and tensile strength related to age were seen in this group. In 20 pairs of femoral heads which were both macroscopically normal, we found, surprisingly, that cartilage from the left and right sides of the same patient was sometimes very different. Compared with the normal autopsy specimens the osteoarthritic specimens had a significantly increased swelling ability, a lower proteoglycan content and impaired mechanical properties, being both weaker in tension and softer in compression. Abnormal autopsy specimens had values intermediate between those of osteoarthritic and normal groups. Results from this abnormal group suggest that there is no primary loss of proteoglycan in early osteoarthritis.
我们研究了22个手术获取的骨关节炎股骨头以及97个尸检获取的股骨头的关节软骨的力学和生化特性。对每个股骨头的顶点及前下方面的软骨进行了拉伸和压缩测试。测量了含水量、肿胀能力和蛋白聚糖含量，对软骨进行了组织学检查，并评估了下方骨骼的密度。55个尸检标本在宏观上被定义为正常，因为它们在用印度墨水染色时未呈现进行性纤维化模式；但在该组中观察到与年龄相关的含水量、骨密度和拉伸强度的显著变化。在20对宏观上均正常的股骨头中，我们惊讶地发现，同一患者左右两侧的软骨有时差异很大。与正常尸检标本相比，骨关节炎标本的肿胀能力显著增加，蛋白聚糖含量较低，力学性能受损，拉伸强度较弱且压缩时较软。异常尸检标本的值介于骨关节炎组和正常组之间。该异常组的结果表明，早期骨关节炎中不存在蛋白聚糖的原发性丢失。
