Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of the Geriatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Int J Environ Res Public Health. 2021 Aug 3;18(15):8231. doi: 10.3390/ijerph18158231.
Myocardial ischemia is the major cause of death worldwide, and reperfusion is the standard intervention for myocardial ischemia. However, reperfusion may cause additional damage, known as myocardial reperfusion injury, for which there is still no effective therapy. This study aims to analyze the landscape of researches concerning myocardial reperfusion injury over the past three decades by machine learning. PubMed was searched for publications from 1990 to 2020 indexed under the Medical Subject Headings (MeSH) term "myocardial reperfusion injury" on 13 April 2021. MeSH analysis and Latent Dirichlet allocation (LDA) analyses were applied to reveal research hotspots. In total, 14,822 publications were collected and analyzed in this study. MeSH analyses revealed that time factors and apoptosis were the leading terms of the pathogenesis and treatment of myocardial reperfusion injury, respectively. In LDA analyses, research topics were classified into three clusters. Complex correlations were observed between topics of different clusters, and the prognosis is the most concerned field of the researchers. In conclusion, the number of publications on myocardial reperfusion injury increases during the past three decades, which mainly focused on prognosis, mechanism, and treatment. Prognosis is the most concerned field, whereas studies on mechanism and treatment are relatively lacking.
心肌缺血是全球范围内主要的死亡原因，再灌注是治疗心肌缺血的标准干预措施。然而，再灌注可能会导致额外的损伤，即心肌再灌注损伤，目前仍然没有有效的治疗方法。本研究旨在通过机器学习分析过去三十年中关于心肌再灌注损伤的研究现状。于 2021 年 4 月 13 日在 PubMed 中检索了 1990 年至 2020 年期间以“心肌再灌注损伤”为主题词索引的出版物。应用 MeSH 分析和潜在狄利克雷分配（LDA）分析来揭示研究热点。本研究共收集和分析了 14822 篇出版物。MeSH 分析显示，时间因素和细胞凋亡分别是心肌再灌注损伤发病机制和治疗的主要术语。在 LDA 分析中，研究主题分为三个聚类。不同聚类的主题之间存在复杂的相关性，预后是研究人员最关注的领域。总之，过去三十年中，关于心肌再灌注损伤的出版物数量不断增加，主要集中在预后、机制和治疗方面。预后是最受关注的领域，而关于机制和治疗的研究相对较少。
