Li Chan, Liu Zhaoya, Shi Ruizheng
Department of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Med (Lausanne). 2023 Jan 19;10:1072359. doi: 10.3389/fmed.2023.1072359. eCollection 2023.
As a cellular process, senescence functions to prevent the proliferation of damaged, old and tumor-like cells, as well as participate in embryonic development, tissue repair, etc. This study aimed to analyze the themes and topics of the scientific publications related to cellular senescence in the past three decades by machine learning.
The MeSH term "cellular senescence" was used for searching publications from 1990 to 2021 on the PubMed database, while the R platform was adopted to obtain associated data. A topic network was constructed by latent Dirichlet allocation (LDA) and the Louvain algorithm.
A total of 21,910 publications were finally recruited in this article. Basic studies (15,382, 70.21%) accounted for the most proportion of publications over the past three decades. Physiology, drug effects, and genetics were the most concerned MeSH terms, while cell proliferation was the leading term since 2010. Three senolytics were indexed by MeSH terms, including quercetin, curcumin, and dasatinib, with the accumulated occurrence of 35, 26, and 22, separately. Three clusters were recognized by LDA and network analyses. Telomere length was the top studied topic in the cluster of physiological function, while cancer cell had been a hot topic in the cluster of pathological function, and protein kinase pathway was the most popular topic in the cluster of molecular mechanism. Notably, the cluster of physiological function showed a poor connection with other clusters.
Cellular senescence has obtained increasing attention over the past three decades. While most of the studies focus on the pathological function and molecular mechanism, more researches should be conducted on the physiological function and the clinical translation of cellular senescence, especially the development and application of senotherapeutics.
作为一种细胞过程，衰老具有防止受损、老化和肿瘤样细胞增殖的功能，同时也参与胚胎发育、组织修复等过程。本研究旨在通过机器学习分析过去三十年中与细胞衰老相关的科学出版物的主题。
使用医学主题词（MeSH）“细胞衰老”在PubMed数据库中检索1990年至2021年的出版物，同时采用R平台获取相关数据。通过潜在狄利克雷分配（LDA）和Louvain算法构建主题网络。
本文最终纳入了21910篇出版物。在过去三十年中，基础研究（15382篇，占70.21%）占出版物的比例最大。生理学、药物作用和遗传学是最受关注的MeSH术语，而自2010年以来细胞增殖是主导术语。有三种衰老细胞溶解剂被MeSH术语索引，包括槲皮素、姜黄素和达沙替尼，累计出现次数分别为35次、26次和22次。通过LDA和网络分析识别出三个聚类。端粒长度是生理功能聚类中研究最多的主题，而癌细胞一直是病理功能聚类中的热门话题，蛋白激酶途径是分子机制聚类中最受欢迎的主题。值得注意的是，生理功能聚类与其他聚类的联系较弱。
在过去三十年中，细胞衰老受到了越来越多的关注。虽然大多数研究集中在病理功能和分子机制上，但应更多地开展关于细胞衰老的生理功能和临床转化的研究，特别是衰老治疗学的开发和应用。
