Addiction Research Group, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.
Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.
Int J Mol Sci. 2021 Jul 23;22(15):7861. doi: 10.3390/ijms22157861.
Neurodevelopmental exposure to psychoactive compounds in cannabis, specifically THC, is associated with a variety of long-term psychopathological outcomes. This increased risk includes a higher prevalence of schizophrenia, mood and anxiety disorders, and cognitive impairments. Clinical and pre-clinical research continues to identify a wide array of underlying neuropathophysiological sequelae and mechanisms that may underlie THC-related psychiatric risk vulnerability, particularly following adolescent cannabis exposure. A common theme among these studies is the ability of developmental THC exposure to induce long-term adaptations in the mesocorticolimbic system which resemble pathological endophenotypes associated with these disorders. This narrative review will summarize recent clinical and pre-clinical evidence that has elucidated these THC-induced developmental risk factors and examine how specific pharmacotherapeutic interventions may serve to reverse or perhaps prevent these cannabis-related risk outcomes.
神经发育过程中接触到大麻中的精神活性化合物，特别是四氢大麻酚（THC），与各种长期精神病理结果相关。这种风险增加包括精神分裂症、情绪和焦虑障碍以及认知障碍的更高患病率。临床和临床前研究继续确定广泛的潜在神经病理生理后果和机制，这些可能是 THC 相关精神风险易感性的基础，特别是在青少年接触大麻之后。这些研究中的一个共同主题是，发育性 THC 暴露能够诱导中边缘皮质系统的长期适应，类似于与这些障碍相关的病理性表型。这篇综述将总结最近阐明这些 THC 诱导的发育风险因素的临床和临床前证据，并探讨特定的药物治疗干预如何可能逆转或预防这些与大麻相关的风险结果。
