Lab of Pharmacology, College of Pharmacy, Dongduk Women's University, Seoul 02748, Korea.
College of Pharmacy, Woosuk University, Wanju-gun 55338, Korea.
Int J Mol Sci. 2021 Jul 23;22(15):7869. doi: 10.3390/ijms22157869.
Autophagy is an attractive process to researchers who are seeking novel potential treatments for various diseases. Autophagy plays a critical role in degrading damaged cellular organelles, supporting normal cell development, and maintaining cellular homeostasis. Because of the various effects of autophagy, recent human genome research has focused on evaluating the relationship between autophagy and a wide variety of diseases, such as autoimmune diseases, cancers, and inflammatory diseases. The skin is the largest organ in the body and provides the first line of defense against environmental hazards, including UV damage, chemical toxins, injuries, oxidative stress, and microorganisms. Autophagy takes part in endogenous defense mechanisms by controlling skin homeostasis. In this manner, regulating autophagy might contribute to the treatment of skin barrier dysfunctions. Various studies are ongoing to elucidate the association between autophagy and skin-related diseases in order to find potential therapeutic approaches. However, little evidence has been gathered about the relationship between autophagy and the skin. In this review, we highlight the previous findings of autophagy and skin barrier disorders and suggest potential therapeutic strategies. The recent research regarding autophagy in acne and skin aging is also discussed.
自噬是研究人员正在寻求各种疾病新的潜在治疗方法的一个有吸引力的过程。自噬在降解受损的细胞细胞器、支持正常细胞发育和维持细胞内环境稳定方面起着关键作用。由于自噬的各种作用，最近的人类基因组研究集中评估了自噬与各种疾病（如自身免疫性疾病、癌症和炎症性疾病）之间的关系。皮肤是人体最大的器官，是抵御环境危害的第一道防线，包括紫外线损伤、化学毒素、损伤、氧化应激和微生物。自噬通过控制皮肤内环境稳态参与内源性防御机制。通过这种方式，调节自噬可能有助于治疗皮肤屏障功能障碍。目前正在进行各种研究，以阐明自噬与皮肤相关疾病之间的关系，以寻找潜在的治疗方法。然而，关于自噬与皮肤之间的关系，我们收集到的证据很少。在这篇综述中，我们重点介绍了自噬和皮肤屏障紊乱的先前发现，并提出了潜在的治疗策略。还讨论了最近关于痤疮和皮肤老化中自噬的研究。
