Division of Infectious Diseases, Cathay General Hospital, Taipei 10630, Taiwan.
Department of Dermatology, Cathay General Hospital, Taipei 10630, Taiwan.
Int J Mol Sci. 2022 May 31;23(11):6172. doi: 10.3390/ijms23116172.
(1) Background: Psoriasis is a T helper 1/T helper 17 cells-involved immune-mediated genetic disease. Lithospermic acid, one of the major phenolic acid compounds of Danshen, has antioxidation and anti-inflammation abilities. Due to the inappropriate molecular weight for topical penetration through the stratum corneum, lithospermic acid was loaded into the well-developed microemulsion delivery system for IMQ-induced psoriasis-like dermatitis treatment. (2) Methods: BALB/c mice were administered with topical imiquimod to induce psoriasis-like dermatitis. Skin barrier function, disease severity, histology assessment, autophagy-related protein expression, and skin and spleen cytokine expression were evaluated. (3) Results: The morphology, histopathology, and skin barrier function results showed that 0.1% lithospermic acid treatment ameliorated the IMQ-induced psoriasis-like dermatitis and restored the skin barrier function. The cytokines array results confirmed that 0.1% lithospermic acid treatment inhibited the cutaneous T helper-17/Interleukin-23 axis related cytokines cascades. (4) Conclusions: The results implied that lithospermic acid might represent a possible new therapeutic agent for psoriasis treatment.
(1) 背景：银屑病是一种 T 辅助细胞 1/T 辅助细胞 17 细胞参与的免疫介导的遗传疾病。丹参中主要的酚酸类化合物之一丹参素酸具有抗氧化和抗炎作用。由于其分子量不适用于通过角质层进行局部渗透，因此将丹参素酸载入到发达的微乳传递系统中，用于治疗咪喹莫特诱导的银屑病样皮炎。
(2) 方法：用局部咪喹莫特处理 BALB/c 小鼠以诱导银屑病样皮炎。评估皮肤屏障功能、疾病严重程度、组织学评估、自噬相关蛋白表达以及皮肤和脾脏细胞因子表达。
(3) 结果：形态学、组织病理学和皮肤屏障功能结果表明，0.1%丹参素酸处理可改善咪喹莫特诱导的银屑病样皮炎并恢复皮肤屏障功能。细胞因子阵列结果证实，0.1%丹参素酸处理抑制了皮肤 T 辅助细胞 17/白细胞介素-23 轴相关细胞因子级联反应。
(4) 结论：结果表明丹参素酸可能是治疗银屑病的一种有前途的新治疗剂。
