Holm J, Hemmingsen L, Nielsen N V, Thomsen M
Department of Clinical Chemistry, Central Hospital Nykøbing Falster, Denmark.
Clin Chim Acta. 1987 Dec;170(2-3):345-9. doi: 10.1016/0009-8981(87)90146-x.
Urinary excretion of the retinol-binding protein (RBP) was studied in 36 insulin-dependent diabetics with serum creatinine concentrations within the normal range and no microalbuminuria. The excretion was significantly (p less than 0.05) higher in the diabetics as compared to a group of apparently healthy persons. The diabetes control indices HbA1 and serum fructosamine showed no correlation to the rate of urinary RBP excretion. The present data support the idea that tubular dysfunction may be an early symptom of diabetic nephropathy.
对36名血清肌酐浓度在正常范围内且无微量白蛋白尿的胰岛素依赖型糖尿病患者的视黄醇结合蛋白（RBP）尿排泄情况进行了研究。与一组明显健康的人相比，糖尿病患者的排泄量显著更高（p < 0.05）。糖尿病控制指标糖化血红蛋白（HbA1）和血清果糖胺与RBP尿排泄率无相关性。目前的数据支持肾小管功能障碍可能是糖尿病肾病早期症状的观点。
