Nielsen N V, Holm J, Hemmingsen L
Department of Ophthalmology, Central Hospital Nykøbing Falster, Denmark.
Acta Ophthalmol (Copenh). 1990 Jun;68(3):270-4. doi: 10.1111/j.1755-3768.1990.tb01921.x.
The urinary excretion of albumin (a marker of glomerular damage) and retinol binding protein (a low molecular weight protein marker of tubular dysfunction) was determined by sensitive immunochemical methods in 110 insulin-dependent (Type I) diabetic patients. We observed a statistically significant correlation between the urinary excretion levels of both proteins, in particular albumin, and the degree of retinopathy. The incidence of macroalbuminuria and tubular proteinuria was significantly higher in patients with manifest background retinopathy and proliferative retinopathy as compared to patients with no or slight retinopathy. The duration of diabetes was significantly correlated to the degree of retinopathy, but not to the urinary excretion of albumin and retinol binding protein.
采用灵敏的免疫化学方法测定了110例胰岛素依赖型（I型）糖尿病患者尿中白蛋白（肾小球损伤标志物）和视黄醇结合蛋白（肾小管功能障碍的低分子量蛋白质标志物）的排泄量。我们观察到这两种蛋白质，尤其是白蛋白的尿排泄水平与视网膜病变程度之间存在统计学上的显著相关性。与无或轻度视网膜病变的患者相比，有明显背景性视网膜病变和增殖性视网膜病变的患者中大量白蛋白尿和肾小管蛋白尿的发生率显著更高。糖尿病病程与视网膜病变程度显著相关，但与白蛋白和视黄醇结合蛋白的尿排泄无关。
