National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Via Portuense 292, 00146 Rome, Italy.
Int J Mol Sci. 2021 Jul 26;22(15):7942. doi: 10.3390/ijms22157942.
In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.
在严重的 COVID-19 中，血液和不同组织中存在血栓和中性粒细胞-血小板聚集体，据报道心血管并发症和静脉血栓栓塞事件的发生率增加。严重感染特征性的炎症风暴可能作为一种驱动因素，能够深刻扰乱血小板、内皮细胞和白细胞之间的复杂相互作用，从而有助于定义 COVID-19 相关的凝血障碍。在这种情况下，P 选择素是一种在内皮细胞和活化血小板上表达的关键分子，有助于内皮细胞激活、白细胞募集、滚动和组织迁移。简而言之，我们描述了 P 选择素在 COVID-19 发病机制中的作用、作为严重程度标志物以及作为宿主导向治疗干预靶点的潜在用途的最新知识状态。
