Wright G L, Rogerson M E, McCumbee W D
Department of Physiology, School of Medicine, Marshall University, Huntington, WV 25704-2901.
Clin Exp Hypertens A. 1987;9(11):1803-11. doi: 10.3109/10641968709158974.
A hypertensive factor (HF) has been partially purified from the erythrocytes of spontaneously hypertensive rats. Injection of the factor produces a sustained elevation of the blood pressure of normotensive rats. The blood pressure response following intravenous injection of the factor is characterized by a prolonged period of onset with maximal elevation obtained several days following the beginning of treatment. Subsequently, the elevation of blood pressure is well maintained and may be observed days or weeks following the cessation of treatment. In addition to its pressor effects, the preparation stimulates an increase in the concentration of "lanthanum-resistant" calcium in aortae excised from normotensive or hypertensive rats. In contrast, the efflux of calcium from aortae in the presence of the factor is enhanced suggesting that the factor involved may induce a change in the lability and exchangeability of calcium stores in aortic tissue. Secondarily, the efflux data indicate that the increase in "lanthanum-resistant" calcium noted in aortae exposed to the erythrocyte extract is due to an increase in calcium uptake by the tissue as opposed to a decrease in the extrusion of the ion.
一种高血压因子（HF）已从自发性高血压大鼠的红细胞中部分纯化出来。注射该因子会使正常血压大鼠的血压持续升高。静脉注射该因子后的血压反应特点是起效时间延长，在治疗开始几天后达到最大血压升高值。随后，血压升高得以很好地维持，并且在停止治疗后的数天或数周内仍可观察到。除了其升压作用外，该制剂还能刺激从正常血压或高血压大鼠切除的主动脉中“镧抗性”钙浓度增加。相反，在该因子存在的情况下，主动脉中钙的流出增强，这表明所涉及的因子可能会引起主动脉组织中钙储备的不稳定性和交换性发生变化。其次，流出数据表明，暴露于红细胞提取物的主动脉中“镧抗性”钙的增加是由于组织对钙的摄取增加，而不是离子外排减少所致。
