Wright G L, Fish S, Johnson P, McCumbee W D
Department of Physiology, Marshall University School of Medicine, Huntington, WV 25704-2901.
Life Sci. 1988;43(2):111-6. doi: 10.1016/0024-3205(88)90287-1.
A peptide was recently isolated from the blood of spontaneously hypertensive (SH) rats that stimulated an increase of calcium uptake by vascular tissue in vitro. In the present study normotensive rats were given nanomolar amounts of this peptide by intravenous or picomolar amounts by intracerebral injection and the effect on blood pressure was recorded. Injection of the peptide into the circulation had no significant effect on the elevation of blood pressure. By comparison, the injection of the compound into the third ventricle of the brain resulted in the elevation of blood pressure to hypertensive levels. The blood pressure response was characterized by a prolonged period of onset with maximal elevation observed several days after the beginning of treatment. Subsequently, the increase in blood pressure was well maintained with significant elevation noted days following the cessation of treatment.
最近从自发性高血压（SH）大鼠血液中分离出一种肽，该肽在体外可刺激血管组织对钙的摄取增加。在本研究中，给正常血压大鼠静脉注射纳摩尔量的这种肽，或脑内注射皮摩尔量的这种肽，并记录对血压的影响。将该肽注入循环系统对血压升高无显著影响。相比之下，将该化合物注入脑第三脑室会导致血压升高至高血压水平。血压反应的特点是起效期延长，在治疗开始几天后观察到血压最大程度升高。随后，血压升高得到很好维持，在停止治疗数天后仍有显著升高。
