Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland.
Int J Mol Sci. 2021 Jul 28;22(15):8056. doi: 10.3390/ijms22158056.
Many matrix metalloproteinases (MMPs) are produced in the mammalian reproductive system and participate in the regulation of its functions. In birds, the limited information available thus far indicates that MMPs are significant regulators of avian ovarian and oviductal functions, too. Some MMPs and inhibitors of MMPs are present in the hen reproductive tissues and their abundances and/or activities change according to the physiological state. The intraovarian role of MMPs likely includes the remodeling of the extracellular matrix (ECM) during folliculogenesis, follicle atresia, and postovulatory regression. In the oviduct, MMPs are also involved in ECM turnover during oviduct development and regression. This study provides a review of the current knowledge on the presence, activity, and regulation of MMPs in the female reproductive system of birds.
许多基质金属蛋白酶（MMPs）在哺乳动物生殖系统中产生，并参与其功能的调节。在鸟类中，目前有限的信息表明 MMPs 也是禽类卵巢和输卵管功能的重要调节剂。一些 MMPs 和 MMPs 的抑制剂存在于母鸡生殖组织中，它们的丰度和/或活性根据生理状态而变化。MMPs 在卵巢内的作用可能包括在卵泡发生、卵泡闭锁和排卵后退化过程中重塑细胞外基质（ECM）。在输卵管中，MMPs 也参与输卵管发育和退化过程中 ECM 的周转。本研究综述了目前关于鸟类雌性生殖系统中 MMPs 的存在、活性和调节的知识。
