新生期链脲佐菌素诱导的2型糖尿病自发性高血压大鼠和正常血压大鼠的血压变化

Blood pressure changes in spontaneously hypertensive and normotensive rats with neonatal streptozotocin induced type 2 diabetes.

作者信息

Iwase M, Kikuchi M, Nunoi K, Wakisaka M, Maki Y, Sadoshima S, Fujishima M

机构信息

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka City, Japan.

出版信息

Clin Exp Hypertens A. 1987;9(12):2157-68. doi: 10.3109/10641968709159081.

DOI:10.3109/10641968709159081

PMID:3436084

Abstract

We examined the blood pressure changes in hypertensive and normotensive rats with Type 2 diabetes induced by neonatal streptozotocin (STZ) treatment. STZ was intraperitoneally injected at 2 days of age with the dose of 25, 50 and 75 mg/kg for male spontaneously hypertensive rats (SHR) and with 75, 100, 125 and 150 mg/kg for male normotensive Wistar Kyoto rats (WKY). Blood pressure was measured by indirect tail-cuff method until 12 weeks of age. STZ-treated SHR, of which plasma glucose and glycosylated hemoglobin increased and body weight decreased with the dose of STZ, developed and maintained hypertension, same as did the vehicle-treated control SHR. On the other hand, STZ-treated WKY which developed only mild hyperglycemia lost body weight with the dose of STZ but the blood pressures rose slightly, these changes being correlated with the glycemic levels. The explanation for these differences between SHR and WKY remained to be elucidated.

摘要

我们研究了新生期经链脲佐菌素（STZ）处理诱导的2型糖尿病高血压和正常血压大鼠的血压变化。雄性自发性高血压大鼠（SHR）在2日龄时腹腔注射STZ，剂量分别为25、50和75 mg/kg，雄性正常血压Wistar Kyoto大鼠（WKY）的注射剂量为75、100、125和150 mg/kg。采用间接尾套法测量血压，直至12周龄。经STZ处理的SHR，其血浆葡萄糖和糖化血红蛋白随STZ剂量增加而升高，体重下降，并出现并维持高血压，与用赋形剂处理的对照SHR相同。另一方面，仅出现轻度高血糖的经STZ处理的WKY随STZ剂量增加体重下降，但血压略有升高，这些变化与血糖水平相关。SHR和WKY之间这些差异的原因仍有待阐明。