Iwase M, Kikuchi M, Nunoi K, Wakisaka M, Maki Y, Sadoshima S, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Diabetes Res Clin Pract. 1987 Nov;4(1):61-5. doi: 10.1016/s0168-8227(87)80034-7.
We examined the sex differences in the development of diabetes due to neonatal streptozotocin (STZ) treatment in spontaneously hypertensive rats (SHR) which are more prone to diabetes than normotensive rats. Male and female SHR were intraperitoneally injected with various doses of STZ at 2 days after birth. In those treated with vehicle or 25 mg/kg of STZ, there were no sex differences in plasma glucose levels, which changed little during the 12 weeks of observation. When treated with 50 mg/kg of STZ, however, male SHR developed overt hyperglycemia greater than 300 mg/dl plasma glucose after 8 weeks of age, while females showed a minimal change in plasma glucose levels. When given 75 mg/kg of STZ, female rats developed overt hyperglycemia at 4-6 weeks of age, during which time male SHR showed no apparent hyperglycemia. At 8 weeks or later, however, both males and females had similarly high levels of plasma glucose. Glycosylated hemoglobin at 12 weeks was compatible with plasma glucose levels in each group. The present results indicate that there are sex differences in susceptibility to neonatal STZ treatment and in development of hyperglycemia.
我们研究了新生期注射链脲佐菌素（STZ）诱导糖尿病的过程中，自发性高血压大鼠（SHR）相较于正常血压大鼠更易患糖尿病的性别差异。雄性和雌性SHR在出生后2天腹腔注射不同剂量的STZ。在接受赋形剂或25mg/kg STZ处理的大鼠中，血浆葡萄糖水平无性别差异，且在12周的观察期内变化不大。然而，当用50mg/kg STZ处理时，雄性SHR在8周龄后出现明显的高血糖，血浆葡萄糖水平超过300mg/dl，而雌性大鼠的血浆葡萄糖水平变化极小。当给予75mg/kg STZ时，雌性大鼠在4至6周龄时出现明显的高血糖，在此期间雄性SHR未出现明显的高血糖。然而，在8周及以后，雄性和雌性大鼠的血浆葡萄糖水平都同样升高。12周时的糖化血红蛋白水平与每组的血浆葡萄糖水平相符。目前的结果表明，新生期STZ处理的易感性以及高血糖的发展存在性别差异。
