School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia.
GENIUROS Research Group, Center for Research in Genetics and Genomics (CIGGUR), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia.
Int J Mol Sci. 2021 Jul 28;22(15):8090. doi: 10.3390/ijms22158090.
Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.
长 QT 综合征可以是获得性的，也可以是先天性的。药物是导致获得性长 QT 综合征的众多病因之一。事实上，许多在临床中经常使用的药物是导致 QT 间期延长的已知危险因素，从而增加尖端扭转型室性心动过速的发生几率。涉及 QT 间期延长的分子机制在大多数药物中是常见的。然而，药物反应在个体之间存在相当大的差异，因此从药物遗传学的角度评估每个个体的风险，使个性化医学的应用成为长 QT 综合征的一个相关方面。
