Department of Pharmacy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
BMC Pharmacol Toxicol. 2022 Jun 14;23(1):39. doi: 10.1186/s40360-022-00582-6.
With an increasing number of reviews describing clinically significant drug-drug interactions (DDIs), the scope and severity of interactions involving commonly used drugs in cardiothoracic intensive care units (CCUs) remain unclear. This study aims to identify risk factors and determine the incidence of potential DDIs in intensive care units.
DDIs were identified based on the profile of the prescribed drug and classified according to the Micromedex drug interaction database. Potential risk factors associated with DDIs have been identified.
A total of 3193 medication episodes were evaluated, and 680 DDIs (21.3%) were found. A total of 203 patients were recruited into the study, with an average of 3.4 DDIs per patient [95% confidence interval (3.2 - 3.6)]. A total of 84.2% of the patients experienced at least one DDI. Anticoagulant and antiplatelet agents were involved in 33.5% (228/680) of the potential drug - drug interactions in the CCU. Univariate analysis and multiple logistic regression analysis showed that the age of the patient and the number of medications prescribed were significantly correlated with the occurrence of DDIs. In multiple linear regression analysis, the number of DDIs had a significant correlation only with the number of prescription drugs.
A high prevalence of DDIs was observed, especially in intensive care units without pharmacist intervention and computerized drug monitoring systems, highlighting the need for active surveillance to prevent potential adverse events.
随着越来越多的文献描述了具有临床意义的药物相互作用（DDI），涉及心胸重症监护病房（CCU）中常用药物的相互作用的范围和严重程度仍不清楚。本研究旨在确定风险因素，并确定重症监护病房中潜在药物相互作用的发生率。
根据规定药物的情况确定药物相互作用，并根据 Micromedex 药物相互作用数据库进行分类。确定与药物相互作用相关的潜在风险因素。
共评估了 3193 个药物疗程，发现 680 个药物相互作用（21.3%）。共招募了 203 名患者，每名患者平均有 3.4 个药物相互作用[95%置信区间（3.2-3.6）]。共有 84.2%的患者发生了至少一次药物相互作用。抗凝和抗血小板药物在 CCU 中涉及 33.5%（228/680）的潜在药物-药物相互作用。单因素分析和多变量逻辑回归分析表明，患者年龄和开处药物数量与药物相互作用的发生显著相关。在多元线性回归分析中，药物相互作用的数量仅与开处药物的数量有显著相关性。
观察到药物相互作用的高发生率，特别是在没有药剂师干预和计算机药物监测系统的重症监护病房，强调需要积极监测以预防潜在的不良事件。
