Decreases SUMOylation Host Response to Promote Intramacrophage Survival.

is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, manipulates host cell response to facilitate its own replication and dissemination. Here, we show that significantly decreases the level of SUMOylation, an essential post-translational modification, in infected macrophages 24 h post-phagocytosis. The reduced level of SUMOylation correlates with a decrease in the SUMO-conjugating enzyme Ubc9. The over-expression of SUMO proteins in macrophages impaired bacterial intracellular proliferation and the inhibition of SUMOylation with ML-792 increased it. Together, these findings demonstrated for the first time the role of host SUMOylation response toward infection.