pH对铜（II）磷酸乙醇胺与嘧啶核苷络合过程的影响
The Influence of pH on Complexation Process of Copper(II) Phosphoethanolamine to Pyrimidine Nucleosides.
作者信息
Gabryel-Skrodzka Malwina, Nowak Martyna, Stachowiak Klaudia, Zabiszak Michal, Ogawa Kazuma, Jastrzab Renata
机构信息
Faculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.
Pharmaceutical Sciences Department, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
出版信息
Materials (Basel). 2021 Aug 1;14(15):4309. doi: 10.3390/ma14154309.
The influence of pH on the complex formation of phosphoethanolamine and pyrimidine nucleosides (uridine, cytidine and thymidine) with copper(II) ions was studied. All investigations were performed in aqueous solution. The overall stability constants of the complexes and non-covalent compounds were obtained using the potentiometric method with computer calculation of the data. Moreover, equilibrium constants of the reaction were determined. The mode of coordination was obtained using spectroscopic methods. Analysis of the potentiometric and spectroscopic data confirmed the involvement and effectiveness of phosphate groups in species formation as well as the influence of pH on the mode of coordination of the investigated biomaterials. In the next step, studied complexes will be applied as potential biomaterials with biological applications.
研究了pH对磷酸乙醇胺与嘧啶核苷（尿苷、胞苷和胸苷）与铜（II）离子形成配合物的影响。所有研究均在水溶液中进行。使用电位滴定法并通过计算机对数据进行计算，获得了配合物和非共价化合物的总稳定常数。此外，还测定了反应的平衡常数。通过光谱方法确定了配位模式。对电位滴定和光谱数据的分析证实了磷酸基团在物种形成中的参与和有效性，以及pH对所研究生物材料配位模式的影响。下一步，将所研究的配合物作为具有生物学应用潜力的生物材料加以应用。
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