Division of Pediatric Allergy and Immunology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
J Trop Pediatr. 2021 Jul 2;67(3). doi: 10.1093/tropej/fmab065.
Oral food challenges (OFCs) assist in the diagnosis of food allergies and are essential to determine whether an allergy has been outgrown. During the OFC, a medical procedure e introduces foods suspected to be allergenic orally in increasing doses. Mild skin reactions such as urticaria or rarely serious life-threatening reactions such as anaphylaxis may develop.
In this study, we aimed to retrospectively evaluate the clinical and laboratory characteristics of patients who experienced anaphylaxis during open OFCs in a tertiary care children's hospital.
Patients who underwent OFCs to confirm the presence of a food allergy or to assess tolerance status at the University of Health Sciences, Ankara, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Pediatric Allergy and Immunology Outpatient Clinic between 1 January 2013 and 1 February 2016, were included in the study. Patients' data were obtained retrospectively from electronic medical records and challenge chart reviews.
A total of 623 OFCs were performed during the period studied. Nine patients (1.4%) between 13 and 67 months of age (mean age: 38.3 months) developed anaphylaxis during their OFC.
OFCs should be performed in a hospital or outpatient office under medical supervision that is adequate for anaphylaxis intervention by an allergy specialist. Close observation of objective and subjective symptoms is essential during the challenge because there are no laboratory tests that can predict an anaphylactic diagnosis or the severity of the reaction.
口服食物挑战（OFC）有助于诊断食物过敏，并对于确定过敏是否已经消除至关重要。在 OFC 过程中，通过医疗程序逐渐增加口服疑似过敏原的食物剂量。可能会出现轻度皮肤反应，如荨麻疹，或罕见的严重危及生命的反应，如过敏反应。
本研究旨在回顾性评估在三级保健儿童医院进行开放 OFC 时发生过敏反应的患者的临床和实验室特征。
在 2013 年 1 月 1 日至 2016 年 2 月 1 日期间，在安卡拉健康科学大学、萨米·乌鲁斯母婴和儿童培训与研究医院儿科过敏和免疫门诊进行 OFC 以确认食物过敏或评估耐受状态的患者被纳入研究。从电子病历和挑战图表回顾中获得患者的数据。
在研究期间共进行了 623 次 OFC。在 13 至 67 个月（平均年龄 38.3 个月）的 9 名患者中，在 OFC 期间发生过敏反应（1.4%）。
OFC 应在过敏专科医生有足够能力进行过敏反应干预的医院或门诊进行。在挑战过程中，必须密切观察客观和主观症状，因为没有实验室检查可以预测过敏反应的诊断或反应的严重程度。
