IRBA: Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France.
INSERM: Institut National de la Santé et de la Recherche Médicale, Paris, France.
Brain Behav. 2021 Aug;11(8):e02163. doi: 10.1002/brb3.2163. Epub 2021 Aug 6.
Post-traumatic stress disorder (PTSD) is a chronic, disabling condition. Our main objective is to investigate the association between trait mindfulness and PTSD over a period of 54 months. The secondary objective is to provide an exhaustive description of PTSD trajectories after the Bataclan attack.
We designed a prospective cohort study of 133 subjects present in the Bataclan concert hall during the November 2015 terrorist attack in Paris, France. Data were recorded 6, 18, 30, and 54 months after the attack. The primary endpoint was evaluated using the PTSD Check List Scale. Trait mindfulness was measured by the 14-item Freiburg Mindfulness Inventory.
FMI scores were consistently, significantly, and negatively associated with PCL-5 scores. Adjusted odds ratios were at 0.81 (6 months), 0.88 (18 months) 0.82 (30 months), and 0.81 (54 months). PTSD prevalence 6 months after the event was 77%; it remained at 41% after 54 months. PTSD status of subjects is fluctuating. Latent class analysis divided the cohort into 3 groups: 21% of subject who remained below PTSD threshold throughout, 30% who remained above throughout, and 49% who steadily reduced their PTSD scores over time.
In our cohort, mindfulness is negatively associated with PTSD. Mindfulness programs are designed to improve global resilience and treat anxiety and mood disorders. Further research is needed to investigate if improving trait mindfulness is possible and beneficial for patients suffering from PTSD.
创伤后应激障碍（PTSD）是一种慢性、致残性疾病。我们的主要目的是在 54 个月的时间内研究特质正念与 PTSD 之间的关系。次要目的是详尽描述巴塔克兰袭击事件后 PTSD 的轨迹。
我们设计了一项前瞻性队列研究，纳入了 133 名在 2015 年 11 月法国巴黎恐怖袭击中身处巴塔克兰音乐厅的受试者。在袭击发生后 6、18、30 和 54 个月时记录数据。使用 PTSD 检查表量表评估主要终点。特质正念通过 14 项 Freiburg 正念量表进行测量。
FMI 评分与 PCL-5 评分始终呈显著负相关。调整后的优势比分别为 0.81（6 个月）、0.88（18 个月）、0.82（30 个月）和 0.81（54 个月）。事件发生后 6 个月 PTSD 的患病率为 77%；54 个月后仍为 41%。受试者的 PTSD 状况是波动的。潜在类别分析将队列分为 3 组：21%的受试者始终低于 PTSD 阈值，30%的受试者始终高于 PTSD 阈值，49%的受试者随着时间的推移稳定降低其 PTSD 评分。
在我们的队列中，正念与 PTSD 呈负相关。正念计划旨在提高整体适应力，治疗焦虑和情绪障碍。需要进一步研究以调查改善特质正念是否可能且有益于患有 PTSD 的患者。
